125 rabbits were classified to 5 groups (25 of each) where the first group was considered as control .The other 4 groups were represented by diseased conditions (Abscess, Snuffles, Enteritis and Mange). The collected samples from different farms from Kalubia government were subjected to chemical examination for evaluation of their quality. The results showed marked highly significant decrease in moisture % in case of enteritis. All diseased cases were significantly decreased specially enteritis and mange in protein %. While, the results of diseased conditions appeared no significant change in fat %. There was slightly significant differences between apparently healthy rabbit meat and diseased conditions in carbohydrate %. Also, it was found slightly significance decrease in results of the diseased conditions rabbit meat than the apparently healthy rabbit meat in ash %.The results showed marked alteration in biochemical examination in almost of the diseased condition which render most of these conditions either unfit for human consumption in severe cases or low quality rabbit meat.