120 random samples of beef kofta, chicken panne, and fish based meal (sushi) (40 of each) , served in Egyptian hotels located in Cairo governorate, Egypt were collected to determine of S.Aureus counts, isolation , identifications and detection of their enterotoxins in the examined samples. The obtained results revealed that S. epidermidis, S. intermedius, S. saprophyticus and S. xylosus were recorded in (25 %), (2.5%), (0%) and (12.5 %) of Kofta , while for chicken panne were detected (37.5 %), (10 %), (7.5%) and (2.5 %) , in add to (45 %), (17.5%), (5%) and (10 %) were detected in Sushi fish samples, furthermore S. aureus was detected in 13(32.5%), 21(52.5%) and 27(67.5%) of the examined kofta, panne and sushi samples Regarding to the edibility of the examined ready to eat ( RTE) samples in relation to its content of S. aureus, 11(27.5%), 21(52.5%) and 27(67.5%) of the examined kofta, panne and sushi samples respectively, were rejected for exceeding S. aureus permissible limit (not more than 102 ). The results recorded als the main values of S . aureus counts in the examined kofta, panne and sushi samples were 9.41×102± 2.12×102, 3.27×103± 0.54×103 and 5.86×103± 0.97×103 cfu/g, respectively. Moreover the incidence for S. aureus enterotoxins positive samples, revealed that SE-A was 1(2.5%), 2(5%) and 4(10%) of the examined kofta, panée and sushi samples, respectively; while SE-B was detected in 1(2.5%) of chicken panée only , while not detected in kofta and sushi samples, SE-D was detected in 1(2.5%) each of kofta and sushi sample , while not detected in panne, SE-A+C was detected in 1(2.5%) of kofta samples while not detected in panne and sushi samples, SE-A+D were detected in 1 (2.5%) each of panne and sushi samples while not detected in kofta samples. Overall, 3(7.5%), 4(10%) and 6(15%) of the examined kofta, panne and sushi . Wherever to the highly obtained results of the S. aureus prevalence, especially enterotoxigenic strains; it encourages investigation of the antibiotic resistance profile molecularly against erythromycin (ermA), gentamicin (aac 6-aph 2), methicillin (mecA) and vancomycin (vanA) resistance genes in randomly collected five S. aureus isolates of each sample and results revealed that out of the examined 15 isolates, 8(53.3%), 5(33.3%), 4(26.6%) and 2(13.3%) were harbored ermA, aac 6-aph 2, mecA and vanA resistance genes, where sushi isolates had the highest prevalence of antibiotic resistance followed by panée and kofta samples, respectively