Endometrial cancer is the commonest gynecological cancer in developed countries and the second most common in developing ones. Aim This study aimed to evaluate the immunohistochemical expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in endometrial hyperplasia and endometrioid adenocarcinoma and its relation with various clinicopathological variables. Moreover, we studied nuclear morphometry to assess the potential risk of patients to develop cancer endometrium. Materials and methods A total of 50 paraffin-embedded tissue blocks from endometrial hyperplasia (15 cases) and endometrioid adenocarcinoma (35 cases) specimens were immunohistochemically studied for EMMPRIN expression. Nuclear morphometric analysis was carried out by means of Olympus soft imaging system to measure the mean nuclear area (MNA), the mean nuclear minimum diameter (Mmnd) and mean nuclear maximum diameter, and mean nuclear ellipsoidy for all cases. Results There was a significantly increased EMMPRIN expression (P