Endometrial cancer is the commonest gynecological cancer in developed countries
and the second most common in developing ones.
Aim
This study aimed to evaluate the immunohistochemical expression of extracellular
matrix metalloproteinase inducer (EMMPRIN) in endometrial hyperplasia and
endometrioid adenocarcinoma and its relation with various clinicopathological
variables. Moreover, we studied nuclear morphometry to assess the potential
risk of patients to develop cancer endometrium.
Materials and methods
A total of 50 paraffin-embedded tissue blocks from endometrial hyperplasia (15
cases) and endometrioid adenocarcinoma (35 cases) specimens were
immunohistochemically studied for EMMPRIN expression. Nuclear
morphometric analysis was carried out by means of Olympus soft imaging
system to measure the mean nuclear area (MNA), the mean nuclear minimum
diameter (Mmnd) and mean nuclear maximum diameter, and mean nuclear
ellipsoidy for all cases.
Results
There was a significantly increased EMMPRIN expression (P