Staff Members - Benha University
Cross talk between oxidative stress and inflammation in alopecia areata
• 2020
Publication Information
Authors
Amany Ibrahim Mustafa MD1 | Rana Atef Khashaba MD2 | Eman Fawzy PhD3 |
Shimaa Mohamad AbdElRahman Baghdady MD4 | Shymaa Mostafa Rezk MD1
Keywords
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Journal
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Although the etiopathogenesis of alopecia areata (AA) is still unclear,
inflammation, oxidative stress, and subsequent DNA damage might be considered
role players in disease development.
Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation
in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG),
high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators,
C-reactive protein (CRP).
Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy
control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP.
Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels
were significantly elevated in the studied patients group (0.031,
inflammation, oxidative stress, and subsequent DNA damage might be considered
role players in disease development.
Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation
in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG),
high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators,
C-reactive protein (CRP).
Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy
control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP.
Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels
were significantly elevated in the studied patients group (0.031,