أعضاء هيئة التدريس - جامعة بنها
Cross talk between oxidative stress and inflammation in alopecia areata
• 2020
معلومات البحث
المؤلفون
Amany Ibrahim Mustafa MD1 | Rana Atef Khashaba MD2 | Eman Fawzy PhD3 |
Shimaa Mohamad AbdElRahman Baghdady MD4 | Shymaa Mostafa Rezk MD1
الكلمات المفتاحية
Not Available
المجلة العلمية
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الناشر
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المجلد
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العدد
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الصفحات
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publication.type
Local
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Although the etiopathogenesis of alopecia areata (AA) is still unclear,
inflammation, oxidative stress, and subsequent DNA damage might be considered
role players in disease development.
Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation
in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG),
high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators,
C-reactive protein (CRP).
Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy
control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP.
Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels
were significantly elevated in the studied patients group (0.031,
inflammation, oxidative stress, and subsequent DNA damage might be considered
role players in disease development.
Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation
in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG),
high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators,
C-reactive protein (CRP).
Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy
control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP.
Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels
were significantly elevated in the studied patients group (0.031,