Staff Members - Benha University
Impact of dietary supplementation of vitamin E (alpha-tocopherol acetate) on genetic expression of inflammatory cytokines and growth efficiency of broiler chickens
benha veterinary medical journal • 2021
Publication Information
Authors
Aya M. Elshwash1, Fatma El-gendy1, Olla A. Khalifa1, Shabaan A. Hemeda2
Keywords
Broilers
Cytokines
Growth efficiency
Humoral immunity
Vitamin E
Journal
benha veterinary medical journal
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
This research was undertaken in order to determine the impact of nutritional vitamin E on
genetic expression of Interferon-gamma (IFN-γ) and Interleukin-1β (IL-1β) as proinflammatory
and Interleukin-4 (IL-4) and Interleukin-10 (IL-10) as anti-inflammatory
cytokines in spleen and liver, hemagglutination inhibition antibody titers (HI titers) against
Newcastle Disease Virus (NDV), total protein, albumin, globulin, and growth efficiency of
broiler chickens. Seventy-two one-day-old Cobb broiler chicks had been allocated randomly
into two groups. Each group has 3 replicates, each with 12 chicks. The first group was given
basal diet (Control). The second group was fed the basal diet with vitamin E (100 mg/kg
diet). The obtained results revealed that dietary supplementation of vitamin E significantly
(P< 0.05) increased growth efficiency, total protein, albumin, globulin, and the antibody titers
to NDV compared to the control. Dietary supplementation of vitamin E significantly (P<
0.05) decreased the expression of pro-inflammatory (IL-1β, IFN-γ) and anti-inflammatory
(IL-4 and IL-10) cytokines in spleen and liver. In Conclusions: vitamin E supplementation
(100 mg/kg diet) can enhance growth efficiency, serum total protein, albumin, globulin, and
humoral immunity, down-regulate pro-inflammatory and anti-inflammatory cytokines gene
expression in broiler chickens.
genetic expression of Interferon-gamma (IFN-γ) and Interleukin-1β (IL-1β) as proinflammatory
and Interleukin-4 (IL-4) and Interleukin-10 (IL-10) as anti-inflammatory
cytokines in spleen and liver, hemagglutination inhibition antibody titers (HI titers) against
Newcastle Disease Virus (NDV), total protein, albumin, globulin, and growth efficiency of
broiler chickens. Seventy-two one-day-old Cobb broiler chicks had been allocated randomly
into two groups. Each group has 3 replicates, each with 12 chicks. The first group was given
basal diet (Control). The second group was fed the basal diet with vitamin E (100 mg/kg
diet). The obtained results revealed that dietary supplementation of vitamin E significantly
(P< 0.05) increased growth efficiency, total protein, albumin, globulin, and the antibody titers
to NDV compared to the control. Dietary supplementation of vitamin E significantly (P<
0.05) decreased the expression of pro-inflammatory (IL-1β, IFN-γ) and anti-inflammatory
(IL-4 and IL-10) cytokines in spleen and liver. In Conclusions: vitamin E supplementation
(100 mg/kg diet) can enhance growth efficiency, serum total protein, albumin, globulin, and
humoral immunity, down-regulate pro-inflammatory and anti-inflammatory cytokines gene
expression in broiler chickens.