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Chronic Zinc Administration Improves Endothelial Cell Function and Vascular Reactivity in Experimentally- Induced Diabetes Mellitus in Rats
Drug Metabolism& Toxicology. Accepted in Second Congress of Pharmacology, Fez, Moracco in September 2002 • 2002
Publication Information
Authors
Mohamed Adel El-Sayed, Nasr N. Zaki, Ahmed S. Mohamed and Sherif W. Mansour
Keywords
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Journal
Drug Metabolism& Toxicology. Accepted in Second Congress of Pharmacology, Fez, Moracco in September 2002
Publisher
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Volume
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Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
An exaggerated oxidative stress has been postulated as the link between diabetes mellitus (D.M) and endothelial dysfunction. This study aimed to investigate the possible therapeutic effect of chronic zinc administration (0.5% rn
drinking water) on renal artery vascular reactivity and oxidative stress indices viz
senrm oxidized to reduced glutathione ratio (GSWGSSG), trolox equivalent
antioxidant capacity (TEAC) and lipohydroperoxides (LPO) in experimentallyinduced
D.M by streptozotocin (STZ) (60 mglkg i.p single dose) in rats. Using
Doppler technique in this study indicated that chronic zinc administration
significantty 1p{O.OS; improved renal artery vascular reactivity to acefylcholine
t[rtrl Such an eftect which seemed to be mediated by two mechanisms: (1) Zinc
iestored plasma antioxidant defenses as it significantly (p
drinking water) on renal artery vascular reactivity and oxidative stress indices viz
senrm oxidized to reduced glutathione ratio (GSWGSSG), trolox equivalent
antioxidant capacity (TEAC) and lipohydroperoxides (LPO) in experimentallyinduced
D.M by streptozotocin (STZ) (60 mglkg i.p single dose) in rats. Using
Doppler technique in this study indicated that chronic zinc administration
significantty 1p{O.OS; improved renal artery vascular reactivity to acefylcholine
t[rtrl Such an eftect which seemed to be mediated by two mechanisms: (1) Zinc
iestored plasma antioxidant defenses as it significantly (p