| publication name | Chronic Zinc Administration Improves Endothelial Cell Function and Vascular Reactivity in Experimentally- Induced Diabetes Mellitus in Rats |
|---|---|
| Authors | Mohamed Adel El-Sayed, Nasr N. Zaki, Ahmed S. Mohamed and Sherif W. Mansour |
| year | 2002 |
| keywords | |
| journal | Drug Metabolism& Toxicology. Accepted in Second Congress of Pharmacology, Fez, Moracco in September 2002 |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
An exaggerated oxidative stress has been postulated as the link between diabetes mellitus (D.M) and endothelial dysfunction. This study aimed to investigate the possible therapeutic effect of chronic zinc administration (0.5% rn drinking water) on renal artery vascular reactivity and oxidative stress indices viz senrm oxidized to reduced glutathione ratio (GSWGSSG), trolox equivalent antioxidant capacity (TEAC) and lipohydroperoxides (LPO) in experimentallyinduced D.M by streptozotocin (STZ) (60 mglkg i.p single dose) in rats. Using Doppler technique in this study indicated that chronic zinc administration significantty 1p{O.OS; improved renal artery vascular reactivity to acefylcholine t[rtrl Such an eftect which seemed to be mediated by two mechanisms: (1) Zinc iestored plasma antioxidant defenses as it significantly (p