أعضاء هيئة التدريس - جامعة بنها
Chronic Zinc Administration Improves Endothelial Cell Function and Vascular Reactivity in Experimentally- Induced Diabetes Mellitus in Rats
Drug Metabolism& Toxicology. Accepted in Second Congress of Pharmacology, Fez, Moracco in September 2002 • 2002
معلومات البحث
المؤلفون
Mohamed Adel El-Sayed, Nasr N. Zaki, Ahmed S. Mohamed and Sherif W. Mansour
الكلمات المفتاحية
Not Available
المجلة العلمية
Drug Metabolism& Toxicology. Accepted in Second Congress of Pharmacology, Fez, Moracco in September 2002
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
An exaggerated oxidative stress has been postulated as the link between diabetes mellitus (D.M) and endothelial dysfunction. This study aimed to investigate the possible therapeutic effect of chronic zinc administration (0.5% rn
drinking water) on renal artery vascular reactivity and oxidative stress indices viz
senrm oxidized to reduced glutathione ratio (GSWGSSG), trolox equivalent
antioxidant capacity (TEAC) and lipohydroperoxides (LPO) in experimentallyinduced
D.M by streptozotocin (STZ) (60 mglkg i.p single dose) in rats. Using
Doppler technique in this study indicated that chronic zinc administration
significantty 1p{O.OS; improved renal artery vascular reactivity to acefylcholine
t[rtrl Such an eftect which seemed to be mediated by two mechanisms: (1) Zinc
iestored plasma antioxidant defenses as it significantly (p
drinking water) on renal artery vascular reactivity and oxidative stress indices viz
senrm oxidized to reduced glutathione ratio (GSWGSSG), trolox equivalent
antioxidant capacity (TEAC) and lipohydroperoxides (LPO) in experimentallyinduced
D.M by streptozotocin (STZ) (60 mglkg i.p single dose) in rats. Using
Doppler technique in this study indicated that chronic zinc administration
significantty 1p{O.OS; improved renal artery vascular reactivity to acefylcholine
t[rtrl Such an eftect which seemed to be mediated by two mechanisms: (1) Zinc
iestored plasma antioxidant defenses as it significantly (p