Staff Members - Benha University
Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway
International Journal of Molecular Sciences • 2022
Publication Information
Authors
Nesrine Ebrahim 1,2,†, Hajir A. Al Saihati 3,†, Ola Mostafa 1
, Amira Hassouna 4
, Sameh Abdulsamea 5
,
Eman Abd El Aziz M. El Gebaly 6
, Nashwa Hassan Abo-Rayah 6 et al
,
Keywords
trastuzumab; doxorubicin; stem cells; exosomes; cardiac toxicity; NRG-1; MAPK; AKT
Journal
International Journal of Molecular Sciences
Publisher
Not Available
Volume
23
Issue
Not Available
Pages
1-36
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor
receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown
potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity.
Mesenchymal stem cells (MSCs)-derived exosomes are nanosized vesicles that play a crucial role in
cell–cell communication and have shown efficacy in the treatment of various diseases. In this study,
we aim to investigate the cardioprotective effects of MSCs-derived exosomes in a DOX/Trz- mediated
cardiotoxicity model, and the possible mechanisms underlying these effects are elucidated. Forty-nine
male rats were randomly assigned into four groups: Group I (control); Group II (Dox/Trz); Group
III (protective group); and Group IV (curative group). Cardiac hemodynamic parameters, serum
markers of cardiac injury, oxidative stress indices, and cardiac histopathology were investigated.
receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown
potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity.
Mesenchymal stem cells (MSCs)-derived exosomes are nanosized vesicles that play a crucial role in
cell–cell communication and have shown efficacy in the treatment of various diseases. In this study,
we aim to investigate the cardioprotective effects of MSCs-derived exosomes in a DOX/Trz- mediated
cardiotoxicity model, and the possible mechanisms underlying these effects are elucidated. Forty-nine
male rats were randomly assigned into four groups: Group I (control); Group II (Dox/Trz); Group
III (protective group); and Group IV (curative group). Cardiac hemodynamic parameters, serum
markers of cardiac injury, oxidative stress indices, and cardiac histopathology were investigated.