أعضاء هيئة التدريس - جامعة بنها
Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway
International Journal of Molecular Sciences • 2022
معلومات البحث
المؤلفون
Nesrine Ebrahim 1,2,†, Hajir A. Al Saihati 3,†, Ola Mostafa 1
, Amira Hassouna 4
, Sameh Abdulsamea 5
,
Eman Abd El Aziz M. El Gebaly 6
, Nashwa Hassan Abo-Rayah 6 et al
,
الكلمات المفتاحية
trastuzumab; doxorubicin; stem cells; exosomes; cardiac toxicity; NRG-1; MAPK; AKT
المجلة العلمية
International Journal of Molecular Sciences
الناشر
Not Available
المجلد
23
العدد
Not Available
الصفحات
1-36
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor
receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown
potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity.
Mesenchymal stem cells (MSCs)-derived exosomes are nanosized vesicles that play a crucial role in
cell–cell communication and have shown efficacy in the treatment of various diseases. In this study,
we aim to investigate the cardioprotective effects of MSCs-derived exosomes in a DOX/Trz- mediated
cardiotoxicity model, and the possible mechanisms underlying these effects are elucidated. Forty-nine
male rats were randomly assigned into four groups: Group I (control); Group II (Dox/Trz); Group
III (protective group); and Group IV (curative group). Cardiac hemodynamic parameters, serum
markers of cardiac injury, oxidative stress indices, and cardiac histopathology were investigated.
receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown
potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity.
Mesenchymal stem cells (MSCs)-derived exosomes are nanosized vesicles that play a crucial role in
cell–cell communication and have shown efficacy in the treatment of various diseases. In this study,
we aim to investigate the cardioprotective effects of MSCs-derived exosomes in a DOX/Trz- mediated
cardiotoxicity model, and the possible mechanisms underlying these effects are elucidated. Forty-nine
male rats were randomly assigned into four groups: Group I (control); Group II (Dox/Trz); Group
III (protective group); and Group IV (curative group). Cardiac hemodynamic parameters, serum
markers of cardiac injury, oxidative stress indices, and cardiac histopathology were investigated.