Staff Members - Benha University
The potential neuroprotective role of mesenchymal stem cell-derived exosomes in cerebellar cortex lipopolysaccharide-induced neuroinflammation in rats: a histological and immunohistochemical study
ULTRASTRUCTURAL PATHOLOGY • 2020
Publication Information
Authors
Abeer Moustfa El-Mahalaway & Nahla El-Eraky El-Azab
Keywords
Cerebellar cortex; exosome;
lipopolysaccharide;
neuroinflammation
Journal
ULTRASTRUCTURAL PATHOLOGY
Publisher
Not Available
Volume
44,
Issue
2
Pages
159–173
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Lipopolysaccharide (LPS) is an endotoxin that prompts neuroinflammation and initiates neurodegenerative disorders. Exosome is a recent therapeutic agent for many diseases such as neurological diseases. This study aimed to evaluate the potential protective role of bone marrow
mesenchymal stem cell-derived exosomes (BMSC-EXs) in cerebellar cortex LPS-induced neuroinflammation in rats. Twenty-seven adult male rats were divided into three groups: Group I: control
rats; Group II: LPS-treated rats; Group III: LPS/BMSC-EXs-treated rats. Cerebellar specimens were
taken and processed for histological and immunohistochemical analysis. Morphometrical studies
and statistical analysis were done. Groups II showed neuronal degeneration and apoptosis. The
mean number of Purkinje cells was significantly (P
mesenchymal stem cell-derived exosomes (BMSC-EXs) in cerebellar cortex LPS-induced neuroinflammation in rats. Twenty-seven adult male rats were divided into three groups: Group I: control
rats; Group II: LPS-treated rats; Group III: LPS/BMSC-EXs-treated rats. Cerebellar specimens were
taken and processed for histological and immunohistochemical analysis. Morphometrical studies
and statistical analysis were done. Groups II showed neuronal degeneration and apoptosis. The
mean number of Purkinje cells was significantly (P