أعضاء هيئة التدريس - جامعة بنها
The potential neuroprotective role of mesenchymal stem cell-derived exosomes in cerebellar cortex lipopolysaccharide-induced neuroinflammation in rats: a histological and immunohistochemical study
ULTRASTRUCTURAL PATHOLOGY • 2020
معلومات البحث
المؤلفون
Abeer Moustfa El-Mahalaway & Nahla El-Eraky El-Azab
الكلمات المفتاحية
Cerebellar cortex; exosome;
lipopolysaccharide;
neuroinflammation
المجلة العلمية
ULTRASTRUCTURAL PATHOLOGY
الناشر
Not Available
المجلد
44,
العدد
2
الصفحات
159–173
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Lipopolysaccharide (LPS) is an endotoxin that prompts neuroinflammation and initiates neurodegenerative disorders. Exosome is a recent therapeutic agent for many diseases such as neurological diseases. This study aimed to evaluate the potential protective role of bone marrow
mesenchymal stem cell-derived exosomes (BMSC-EXs) in cerebellar cortex LPS-induced neuroinflammation in rats. Twenty-seven adult male rats were divided into three groups: Group I: control
rats; Group II: LPS-treated rats; Group III: LPS/BMSC-EXs-treated rats. Cerebellar specimens were
taken and processed for histological and immunohistochemical analysis. Morphometrical studies
and statistical analysis were done. Groups II showed neuronal degeneration and apoptosis. The
mean number of Purkinje cells was significantly (P
mesenchymal stem cell-derived exosomes (BMSC-EXs) in cerebellar cortex LPS-induced neuroinflammation in rats. Twenty-seven adult male rats were divided into three groups: Group I: control
rats; Group II: LPS-treated rats; Group III: LPS/BMSC-EXs-treated rats. Cerebellar specimens were
taken and processed for histological and immunohistochemical analysis. Morphometrical studies
and statistical analysis were done. Groups II showed neuronal degeneration and apoptosis. The
mean number of Purkinje cells was significantly (P