Staff Members - Benha University
Impacts of resveratrol versus platelet-rich plasma for treatment of experimentally lithium-induced thyroid follicular cell toxicity in rats. A histological and immunohistochemical study
ULTRASTRUCTURAL PATHOLOGY • 2019
Publication Information
Authors
Abeer M. El-Mahalaway & Nahla El-Eraky El-Azab
Keywords
Lithium; P53; PRP;
resveratrol; thyroid follicular
cells
Journal
ULTRASTRUCTURAL PATHOLOGY
Publisher
Not Available
Volume
43
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Lithium (Li) is used for the treatment and prophylaxis of mental disorders, associated with many
serious hazards. Resveratrol (RSV) has various beneficial therapeutic effects. Platelet-rich plasma
(PRP) is a new promising curative tool. This study aimed to assess the impacts of RSV versus PRP
on lithium-induced thyroid follicular cell toxicity in adult male rats. Forty-nine adult male rats were
divided into four groups: group I: control rats; group II: lithium-treated rats; group III: lithium- and
resveratrol-treated rats; group IV: lithium and PRP-treated rats. Thyroid specimens were taken and
processed for histological and immunohistochemical methods. Morphometrical studies and statistical analysis were done. Group II showed distorted thyroid follicles, significantly increased
collagen fibers, and highly positive P53 immunostaining (P < 0.01). Ultrastructural examination
showed dilated rough endoplasmic reticulum and damaged mitochondria. Groups III and IV
exhibited significant amelioration of the histological and electron microscopic changes mentioned
previously. PRP remedy was more effective than RSV for treatment of Li-induced thyroid follicular
cell toxicity.
serious hazards. Resveratrol (RSV) has various beneficial therapeutic effects. Platelet-rich plasma
(PRP) is a new promising curative tool. This study aimed to assess the impacts of RSV versus PRP
on lithium-induced thyroid follicular cell toxicity in adult male rats. Forty-nine adult male rats were
divided into four groups: group I: control rats; group II: lithium-treated rats; group III: lithium- and
resveratrol-treated rats; group IV: lithium and PRP-treated rats. Thyroid specimens were taken and
processed for histological and immunohistochemical methods. Morphometrical studies and statistical analysis were done. Group II showed distorted thyroid follicles, significantly increased
collagen fibers, and highly positive P53 immunostaining (P < 0.01). Ultrastructural examination
showed dilated rough endoplasmic reticulum and damaged mitochondria. Groups III and IV
exhibited significant amelioration of the histological and electron microscopic changes mentioned
previously. PRP remedy was more effective than RSV for treatment of Li-induced thyroid follicular
cell toxicity.