Lithium (Li) is used for the treatment and prophylaxis of mental disorders, associated with many
serious hazards. Resveratrol (RSV) has various beneficial therapeutic effects. Platelet-rich plasma
(PRP) is a new promising curative tool. This study aimed to assess the impacts of RSV versus PRP
on lithium-induced thyroid follicular cell toxicity in adult male rats. Forty-nine adult male rats were
divided into four groups: group I: control rats; group II: lithium-treated rats; group III: lithium- and
resveratrol-treated rats; group IV: lithium and PRP-treated rats. Thyroid specimens were taken and
processed for histological and immunohistochemical methods. Morphometrical studies and statistical analysis were done. Group II showed distorted thyroid follicles, significantly increased
collagen fibers, and highly positive P53 immunostaining (P < 0.01). Ultrastructural examination
showed dilated rough endoplasmic reticulum and damaged mitochondria. Groups III and IV
exhibited significant amelioration of the histological and electron microscopic changes mentioned
previously. PRP remedy was more effective than RSV for treatment of Li-induced thyroid follicular
cell toxicity.