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Telomere Length Measurement by Quantitative Real-time PCR: A Molecular Marker for Human Age Prediction

american journal of biochemistry and molecular biology • 2016
العودة
معلومات البحث
المؤلفون Naglaa F. Alhusseini and Abdelmonem G. Madboly
الكلمات المفتاحية Not Available
المجلة العلمية american journal of biochemistry and molecular biology
الناشر science publication
المجلد 12
العدد 1
الصفحات 64-71
publication.type International
رابط البحث Open Link
المواد المرفقة Not Available
الملخص
The fact that telomere shortening occurs with aging leads to the hypothesis that a correlation could be made between Telomere Length (TL) and suspect age. This study aimed to assess if TL can be used as an investigational tool to predict human age through developing a formula based on this correlation with accuracy suitable to be applied in forensic practice. A quantitative real-time PCR study was carried out on 80 Egyptians, ranging in age from 1-79 years. The results confirmed that the relative TL significantly shortened with aging; “r” = -0.903 (p