Telomere Length Measurement by Quantitative Real-time PCR: A Molecular Marker for Human Age Prediction
american journal of biochemistry and molecular biology • 2016
Publication Information
Authors
Naglaa F. Alhusseini and Abdelmonem G. Madboly
Keywords
Not Available
Journal
american journal of biochemistry and molecular biology
Publisher
science publication
Volume
12
Issue
1
Pages
64-71
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
The fact that telomere shortening occurs with aging leads to the hypothesis that a correlation could be made between Telomere Length (TL) and suspect age. This study aimed to assess if TL can be used as an investigational tool to predict human age through developing a formula based on this correlation with accuracy suitable to be applied in forensic practice. A quantitative real-time PCR study was carried out on 80 Egyptians, ranging in age from 1-79 years. The results confirmed that the relative TL significantly shortened with aging; “r” = -0.903 (p
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