Staff Members - Benha University
Role of peroxisome proliferator-activated receptor-gamma in alleviating non-alcoholic steatohepatitis (NASH) induced in rats by thymoquinone
• 2014
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Authors
AzzaSayedMAwada,EkramNemrAbd Al Haleema, Wesam M El-Baklyb, Mohie A. Sheriefc aDepartment of Pharmacology and Toxicology, Faculty of Pharmacy for Girls, Al-Azhar University, Nasr City, Cairo, Egypt b Department of Pharmacology, Faculty of Medicine, Ain Sh
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Abstract
Background and Aim:Nonalcoholicsteatohepatitis (NASH) is a progressive form of liver disease that leads to advanced fibrosis. Its pathogenesis is not fully known and no specific therapeutic agents are available. Oxidative stress and inflammation play an important role in the progression from simple fatty liver to NASH. Insulin resistance (IR) is commonly associated with it. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) may also play a role in the pathogenesis of NASH. The present study was designed to assess the effects ofthymoquinone (TQ) on liver functions, insulin resistance and PPAR-