Staff Members - Benha University
CINNAMON EXTRACT REGULATES GENE EXPRESSION OF LIPID AND CARBOHYDRATE METABOLISM IN STREPTOZOTOCIN INDUCED DIABETIC WISTAR RATS
• 2013
Publication Information
Authors
Mohamed Mohamed Soliman, Mohamed Mohamed Ahmed and Samir Ahmed El-Shazly
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Cinnamon is a herbal medication plant used widely for many diseases in the Middle East and ancient
countries. Cinnamon Extract (CE) contains many active substances that modulate insulin sensitivity and
acts as anti-diabetic medication. Diabetes mellitus is a disease characterized by disturbance in carbohydrate
and lipid metabolism. The aim of this study was to examine the effect of Cinnamon Extract (CE, 200 mg
kg-1 body weight) on genes expression of lipid and carbohydrate metabolism in Streptozotocin (STZ)
induced diabetes in Wistar rats. Administration of CE to STZ diabetic rats for 2 months normalized TG,
cholesterol, VLDL, HDL and glucose levels. CE administration increased FAS and STREB-1c gene
expressions that were inhibited in diabetic rats. Moreover, CE inhibited significantly the increase in LPL,
HSL and resistin expression. In parallel, CE increased the expression of PPECK and GLUT2 and inhibited
the decrement in IGF and PK expression. In conclusion, CE regulates the expression of genes related to
lipid and carbohydrate metabolism in a way to control the metabolic disorders occur during diabetes.
countries. Cinnamon Extract (CE) contains many active substances that modulate insulin sensitivity and
acts as anti-diabetic medication. Diabetes mellitus is a disease characterized by disturbance in carbohydrate
and lipid metabolism. The aim of this study was to examine the effect of Cinnamon Extract (CE, 200 mg
kg-1 body weight) on genes expression of lipid and carbohydrate metabolism in Streptozotocin (STZ)
induced diabetes in Wistar rats. Administration of CE to STZ diabetic rats for 2 months normalized TG,
cholesterol, VLDL, HDL and glucose levels. CE administration increased FAS and STREB-1c gene
expressions that were inhibited in diabetic rats. Moreover, CE inhibited significantly the increase in LPL,
HSL and resistin expression. In parallel, CE increased the expression of PPECK and GLUT2 and inhibited
the decrement in IGF and PK expression. In conclusion, CE regulates the expression of genes related to
lipid and carbohydrate metabolism in a way to control the metabolic disorders occur during diabetes.