Cinnamon is a herbal medication plant used widely for many diseases in the Middle East and ancient
countries. Cinnamon Extract (CE) contains many active substances that modulate insulin sensitivity and
acts as anti-diabetic medication. Diabetes mellitus is a disease characterized by disturbance in carbohydrate
and lipid metabolism. The aim of this study was to examine the effect of Cinnamon Extract (CE, 200 mg
kg-1 body weight) on genes expression of lipid and carbohydrate metabolism in Streptozotocin (STZ)
induced diabetes in Wistar rats. Administration of CE to STZ diabetic rats for 2 months normalized TG,
cholesterol, VLDL, HDL and glucose levels. CE administration increased FAS and STREB-1c gene
expressions that were inhibited in diabetic rats. Moreover, CE inhibited significantly the increase in LPL,
HSL and resistin expression. In parallel, CE increased the expression of PPECK and GLUT2 and inhibited
the decrement in IGF and PK expression. In conclusion, CE regulates the expression of genes related to
lipid and carbohydrate metabolism in a way to control the metabolic disorders occur during diabetes.