Staff Members - Benha University
Regioselective synthesis, antitumor and antioxidant activities of some 1,2,4-triazole derivatives based on 4-phenyl-5-(quinolin-8- yloxy)methyl-4H-1,2,4-triazole-3-thiol
PHOSPHORUS, SULFUR, AND SILICON • 2016
Publication Information
Authors
M. S. Behalo, M. S. Amine & I. M. Fouda
Keywords
Quinoline; triazole; pyrazole;
thiazole; antitumor;
antioxidant
Journal
PHOSPHORUS, SULFUR, AND SILICON
Publisher
Taylor, Francis
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Regioselective synthesis of sometriazole derivatives 4–18 was achieved fromthe versatile, readily accessible
4-phenyl-5-(quinolin-8-yloxy)methyl-4H-1,2,4-triazole-3-thiol/thione 3. The structures of the newly synthesized
products were confirmed and characterized by IR, 1H NMR, 13C NMR, and mass spectral studies. Most
of the synthesized compounds were evaluated for their antitumor and antioxidant activities and demonstrated
potent to weak activities.
4-phenyl-5-(quinolin-8-yloxy)methyl-4H-1,2,4-triazole-3-thiol/thione 3. The structures of the newly synthesized
products were confirmed and characterized by IR, 1H NMR, 13C NMR, and mass spectral studies. Most
of the synthesized compounds were evaluated for their antitumor and antioxidant activities and demonstrated
potent to weak activities.