أعضاء هيئة التدريس - جامعة بنها
study of phenotypic characteristic and HLA types in egyptian NIDDM patients with and without glutamic acid decarboxylase antibodies under different modalities of treatment
sci.med. j., escme • 2000
معلومات البحث
المؤلفون
mohamed Shawky,AhmedSalehandMahaYoussef*.
الكلمات المفتاحية
Not Available
المجلة العلمية
sci.med. j., escme
الناشر
Not Available
المجلد
12, no. 3, july., 2000
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
ABSTRACT
.» t.it work was designed to studytheprevalenceofglutamicacid
antibodies (GADab) in representatives ofEgyptianNIDDMpatients
‘
' thephenotypiccharacteristicsandHLAtypesofthissubgroup.
,
I dnon—insulintreatedtype2 diabeticpatients(GroupI),50insulin
‘ Jabeticpatients(GroupII)and50healthyvolunteersservingascontrols
constitutedthe subjectsofourstudy.Theageofpatientsrangedbetween
a otype wasassessedbypatient'sage,ageofonsetofdiabetes,bodymass
, plasma glucose, percentage hemoglobin AIc (Hb A1c), serum
serumtriglycerides andserumC-peptidelevel. GADabwasmeasured
method.ClassIHLA(I-ILA-AandB)andclassIIHLA(HLA-DR)types
».
r
4 usingcytotoxicitytest.
’ prevalence ofGADabwas20%amonggroup1patients,60%amonggroup
_ . and4%amongcontrols. TheGADabpositiv'epatientsweresignificantly
andexperienceddiabetes onsetatanearlieragecomparedwithGADab
patients. The GADab positive patients had lowerfastingC—peptide
'on in comparisonwith GADabnegativepatients.Withrespecttofeatures
a 'c syndrome, theGADabpositivepatients hadlowerBMI,lowerserum
“
. 1‘ lowerserumtriglycerides, higherplasmaglucoseandhigherHbA[c
-» with GADabnegative patients.ComparedwithGADabnegativepatients
ols, groupIIpatientshadanincreasedfrequencyofHLADR3andDR4
HerewerenodtflerencesbetweenNIDDMandnormalcontrolsinthefrequency
particularHLAantigen exceptforanincreasedfrequencyofHLAB18inboth
« Iand11patientsandincreasedfrequencyofHLADR?/DR4ingroup11patients.
Uteseresultssuggestthattype2diabetesisaheterogeneousdisorderincludingat
t 2majorsubgroupscharacterizedbyGADabandHLDR3/DR4types.
.» t.it work was designed to studytheprevalenceofglutamicacid
antibodies (GADab) in representatives ofEgyptianNIDDMpatients
‘
' thephenotypiccharacteristicsandHLAtypesofthissubgroup.
,
I dnon—insulintreatedtype2 diabeticpatients(GroupI),50insulin
‘ Jabeticpatients(GroupII)and50healthyvolunteersservingascontrols
constitutedthe subjectsofourstudy.Theageofpatientsrangedbetween
a otype wasassessedbypatient'sage,ageofonsetofdiabetes,bodymass
, plasma glucose, percentage hemoglobin AIc (Hb A1c), serum
serumtriglycerides andserumC-peptidelevel. GADabwasmeasured
method.ClassIHLA(I-ILA-AandB)andclassIIHLA(HLA-DR)types
».
r
4 usingcytotoxicitytest.
’ prevalence ofGADabwas20%amonggroup1patients,60%amonggroup
_ . and4%amongcontrols. TheGADabpositiv'epatientsweresignificantly
andexperienceddiabetes onsetatanearlieragecomparedwithGADab
patients. The GADab positive patients had lowerfastingC—peptide
'on in comparisonwith GADabnegativepatients.Withrespecttofeatures
a 'c syndrome, theGADabpositivepatients hadlowerBMI,lowerserum
“
. 1‘ lowerserumtriglycerides, higherplasmaglucoseandhigherHbA[c
-» with GADabnegative patients.ComparedwithGADabnegativepatients
ols, groupIIpatientshadanincreasedfrequencyofHLADR3andDR4
HerewerenodtflerencesbetweenNIDDMandnormalcontrolsinthefrequency
particularHLAantigen exceptforanincreasedfrequencyofHLAB18inboth
« Iand11patientsandincreasedfrequencyofHLADR?/DR4ingroup11patients.
Uteseresultssuggestthattype2diabetesisaheterogeneousdisorderincludingat
t 2majorsubgroupscharacterizedbyGADabandHLDR3/DR4types.