| publication name | study of phenotypic characteristic and HLA types in egyptian NIDDM patients with and without glutamic acid decarboxylase antibodies under different modalities of treatment |
|---|---|
| Authors | mohamed Shawky,AhmedSalehandMahaYoussef*. |
| year | 2000 |
| keywords | |
| journal | sci.med. j., escme |
| volume | 12, no. 3, july., 2000 |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
ABSTRACT .» t.it work was designed to studytheprevalenceofglutamicacid antibodies (GADab) in representatives ofEgyptianNIDDMpatients ‘ ' thephenotypiccharacteristicsandHLAtypesofthissubgroup. , I dnon—insulintreatedtype2 diabeticpatients(GroupI),50insulin ‘ Jabeticpatients(GroupII)and50healthyvolunteersservingascontrols constitutedthe subjectsofourstudy.Theageofpatientsrangedbetween a otype wasassessedbypatient'sage,ageofonsetofdiabetes,bodymass , plasma glucose, percentage hemoglobin AIc (Hb A1c), serum serumtriglycerides andserumC-peptidelevel. GADabwasmeasured method.ClassIHLA(I-ILA-AandB)andclassIIHLA(HLA-DR)types ». r 4 usingcytotoxicitytest. ’ prevalence ofGADabwas20%amonggroup1patients,60%amonggroup _ . and4%amongcontrols. TheGADabpositiv'epatientsweresignificantly andexperienceddiabetes onsetatanearlieragecomparedwithGADab patients. The GADab positive patients had lowerfastingC—peptide 'on in comparisonwith GADabnegativepatients.Withrespecttofeatures a 'c syndrome, theGADabpositivepatients hadlowerBMI,lowerserum “ . 1‘ lowerserumtriglycerides, higherplasmaglucoseandhigherHbA[c -» with GADabnegative patients.ComparedwithGADabnegativepatients ols, groupIIpatientshadanincreasedfrequencyofHLADR3andDR4 HerewerenodtflerencesbetweenNIDDMandnormalcontrolsinthefrequency particularHLAantigen exceptforanincreasedfrequencyofHLAB18inboth « Iand11patientsandincreasedfrequencyofHLADR?/DR4ingroup11patients. Uteseresultssuggestthattype2diabetesisaheterogeneousdisorderincludingat t 2majorsubgroupscharacterizedbyGADabandHLDR3/DR4types.