Staff Members - Benha University
study of phenotypic characteristic and HLA types in egyptian NIDDM patients with and without glutamic acid decarboxylase antibodies under different modalities of treatment
sci.med. j., escme • 2000
Publication Information
Authors
mohamed Shawky,AhmedSalehandMahaYoussef*.
Keywords
Not Available
Journal
sci.med. j., escme
Publisher
Not Available
Volume
12, no. 3, july., 2000
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
ABSTRACT
.» t.it work was designed to studytheprevalenceofglutamicacid
antibodies (GADab) in representatives ofEgyptianNIDDMpatients
‘
' thephenotypiccharacteristicsandHLAtypesofthissubgroup.
,
I dnon—insulintreatedtype2 diabeticpatients(GroupI),50insulin
‘ Jabeticpatients(GroupII)and50healthyvolunteersservingascontrols
constitutedthe subjectsofourstudy.Theageofpatientsrangedbetween
a otype wasassessedbypatient'sage,ageofonsetofdiabetes,bodymass
, plasma glucose, percentage hemoglobin AIc (Hb A1c), serum
serumtriglycerides andserumC-peptidelevel. GADabwasmeasured
method.ClassIHLA(I-ILA-AandB)andclassIIHLA(HLA-DR)types
».
r
4 usingcytotoxicitytest.
’ prevalence ofGADabwas20%amonggroup1patients,60%amonggroup
_ . and4%amongcontrols. TheGADabpositiv'epatientsweresignificantly
andexperienceddiabetes onsetatanearlieragecomparedwithGADab
patients. The GADab positive patients had lowerfastingC—peptide
'on in comparisonwith GADabnegativepatients.Withrespecttofeatures
a 'c syndrome, theGADabpositivepatients hadlowerBMI,lowerserum
“
. 1‘ lowerserumtriglycerides, higherplasmaglucoseandhigherHbA[c
-» with GADabnegative patients.ComparedwithGADabnegativepatients
ols, groupIIpatientshadanincreasedfrequencyofHLADR3andDR4
HerewerenodtflerencesbetweenNIDDMandnormalcontrolsinthefrequency
particularHLAantigen exceptforanincreasedfrequencyofHLAB18inboth
« Iand11patientsandincreasedfrequencyofHLADR?/DR4ingroup11patients.
Uteseresultssuggestthattype2diabetesisaheterogeneousdisorderincludingat
t 2majorsubgroupscharacterizedbyGADabandHLDR3/DR4types.
.» t.it work was designed to studytheprevalenceofglutamicacid
antibodies (GADab) in representatives ofEgyptianNIDDMpatients
‘
' thephenotypiccharacteristicsandHLAtypesofthissubgroup.
,
I dnon—insulintreatedtype2 diabeticpatients(GroupI),50insulin
‘ Jabeticpatients(GroupII)and50healthyvolunteersservingascontrols
constitutedthe subjectsofourstudy.Theageofpatientsrangedbetween
a otype wasassessedbypatient'sage,ageofonsetofdiabetes,bodymass
, plasma glucose, percentage hemoglobin AIc (Hb A1c), serum
serumtriglycerides andserumC-peptidelevel. GADabwasmeasured
method.ClassIHLA(I-ILA-AandB)andclassIIHLA(HLA-DR)types
».
r
4 usingcytotoxicitytest.
’ prevalence ofGADabwas20%amonggroup1patients,60%amonggroup
_ . and4%amongcontrols. TheGADabpositiv'epatientsweresignificantly
andexperienceddiabetes onsetatanearlieragecomparedwithGADab
patients. The GADab positive patients had lowerfastingC—peptide
'on in comparisonwith GADabnegativepatients.Withrespecttofeatures
a 'c syndrome, theGADabpositivepatients hadlowerBMI,lowerserum
“
. 1‘ lowerserumtriglycerides, higherplasmaglucoseandhigherHbA[c
-» with GADabnegative patients.ComparedwithGADabnegativepatients
ols, groupIIpatientshadanincreasedfrequencyofHLADR3andDR4
HerewerenodtflerencesbetweenNIDDMandnormalcontrolsinthefrequency
particularHLAantigen exceptforanincreasedfrequencyofHLAB18inboth
« Iand11patientsandincreasedfrequencyofHLADR?/DR4ingroup11patients.
Uteseresultssuggestthattype2diabetesisaheterogeneousdisorderincludingat
t 2majorsubgroupscharacterizedbyGADabandHLDR3/DR4types.