Staff Members - Benha University
METHOD OF PRODUCTION OF POLYANIONIC DRUG CARRIER CONJUGATES
United States Patent • 2014
Publication Information
Authors
BORATYNSKI JANUSZ
MEGAHED MOHAMED SALAH OMAR
KANSKA URSZULA
NEVOZHAY DMITRY
WIETRZYK JOANNA
Keywords
Not Available
Journal
United States Patent
Publisher
Not Available
Volume
US 8,623,998 B2
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
The invention concerns the method of production of a polya
nionic macromolecule which is a protein built, among others,
from polar amino acids such as lysine, arginine, aspartic acid,
glutamic acid), characteristic in that, as a result of the reaction
between amine groups and the cyclic anhydride of dicarboxy
lic acid, the charge changes towards more negatively charged
carrier. This reaction gives rise to better therapeutic properties
of macromolecules modi?ed in this way.
nionic macromolecule which is a protein built, among others,
from polar amino acids such as lysine, arginine, aspartic acid,
glutamic acid), characteristic in that, as a result of the reaction
between amine groups and the cyclic anhydride of dicarboxy
lic acid, the charge changes towards more negatively charged
carrier. This reaction gives rise to better therapeutic properties
of macromolecules modi?ed in this way.