The invention concerns the method of production of a polya
nionic macromolecule which is a protein built, among others,
from polar amino acids such as lysine, arginine, aspartic acid,
glutamic acid), characteristic in that, as a result of the reaction
between amine groups and the cyclic anhydride of dicarboxy
lic acid, the charge changes towards more negatively charged
carrier. This reaction gives rise to better therapeutic properties
of macromolecules modi?ed in this way.