| publication name | Studyofvisfatinlevelanditsrelationtosomehistopathologicalchanges ofplacentaeinpreeclampsi |
|---|---|
| Authors | :M.A.Megahed,S.M.Dawoud,A.I.El-Sarha,M.A.Fayed,andM.I.Ahme |
| year | 2016 |
| keywords | Visfatin,Preeclampsia,Insulinresistance,Placenta,Infarction,Atherosis,Hyalinized areas,TennyParkerchanges |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Objective:Tomeasuretheserum levelofvisfatininpreeclampticEgyptianpregnantwomenand thepossiblerelationofvisfatinleveltoeachofthemeasuredinsulinresistance,bodymassindex andhistopathologicalchangesoftheplacentaincludedinthisstudy. Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy pregnantwomenduringthethirdtrimester. Results:Thepresentstudyresultsrevealedthatpreeclampticmothershadasignificantincreasein insulinresistancevaluethannormalpregnantwomenwithnosignificantdifferenceinthisvalue betweenmildandseverepreeclampticsub-groups.Regardingvisfatinlevel,therewasahighly significantincreaseinvisfatinlevelinpreeclampticwomencomparedwithhealthycontrolsand alsoincreaseinseverethanmildpreeclampticsub-groups.Correlationanalysispresenteda significantnegative correlation between maternalvisfatin levelsversusHOMA-IR among preeclampticgroup,butnorelationhadbeenfoundbetweenvisfatinlevelsandbodymassindex amongpreeclampticmothers.Histopathologicalexaminationofplacentaerevealedthatinfarctions, atherosis,hyalinizedareasandTennyParkerschangesweresignificantlyincreasedinpreeclamptic groupthancontrolgroup.Thepresentstudydidnotfoundanycorrelationsbetweenvisfatinlevels versushistopathologicalchangesinplacentaeamongpreeclampticmothers. Conclusions:Hypervisfatinemia maybeoneofthepossibleetiologiesofpreeclampsia.Visfatin mightbepartofafeedbackmechanism improvinginsulinsensitivity.Preeclampticplacentae exhibiteddefinitehistopathologicalchangeswhichmaybeattributedtothevascularinsufficiency ofplacenta