أعضاء هيئة التدريس - جامعة بنها
Studyofvisfatinlevelanditsrelationtosomehistopathologicalchanges ofplacentaeinpreeclampsi
• 2016
معلومات البحث
المؤلفون
:M.A.Megahed,S.M.Dawoud,A.I.El-Sarha,M.A.Fayed,andM.I.Ahme
الكلمات المفتاحية
Visfatin,Preeclampsia,Insulinresistance,Placenta,Infarction,Atherosis,Hyalinized
areas,TennyParkerchanges
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Objective:Tomeasuretheserum levelofvisfatininpreeclampticEgyptianpregnantwomenand
thepossiblerelationofvisfatinleveltoeachofthemeasuredinsulinresistance,bodymassindex
andhistopathologicalchangesoftheplacentaincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Thepresentstudyresultsrevealedthatpreeclampticmothershadasignificantincreasein
insulinresistancevaluethannormalpregnantwomenwithnosignificantdifferenceinthisvalue
betweenmildandseverepreeclampticsub-groups.Regardingvisfatinlevel,therewasahighly
significantincreaseinvisfatinlevelinpreeclampticwomencomparedwithhealthycontrolsand
alsoincreaseinseverethanmildpreeclampticsub-groups.Correlationanalysispresenteda
significantnegative correlation between maternalvisfatin levelsversusHOMA-IR among
preeclampticgroup,butnorelationhadbeenfoundbetweenvisfatinlevelsandbodymassindex
amongpreeclampticmothers.Histopathologicalexaminationofplacentaerevealedthatinfarctions,
atherosis,hyalinizedareasandTennyParkerschangesweresignificantlyincreasedinpreeclamptic
groupthancontrolgroup.Thepresentstudydidnotfoundanycorrelationsbetweenvisfatinlevels
versushistopathologicalchangesinplacentaeamongpreeclampticmothers.
Conclusions:Hypervisfatinemia maybeoneofthepossibleetiologiesofpreeclampsia.Visfatin
mightbepartofafeedbackmechanism improvinginsulinsensitivity.Preeclampticplacentae
exhibiteddefinitehistopathologicalchangeswhichmaybeattributedtothevascularinsufficiency
ofplacenta
thepossiblerelationofvisfatinleveltoeachofthemeasuredinsulinresistance,bodymassindex
andhistopathologicalchangesoftheplacentaincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Thepresentstudyresultsrevealedthatpreeclampticmothershadasignificantincreasein
insulinresistancevaluethannormalpregnantwomenwithnosignificantdifferenceinthisvalue
betweenmildandseverepreeclampticsub-groups.Regardingvisfatinlevel,therewasahighly
significantincreaseinvisfatinlevelinpreeclampticwomencomparedwithhealthycontrolsand
alsoincreaseinseverethanmildpreeclampticsub-groups.Correlationanalysispresenteda
significantnegative correlation between maternalvisfatin levelsversusHOMA-IR among
preeclampticgroup,butnorelationhadbeenfoundbetweenvisfatinlevelsandbodymassindex
amongpreeclampticmothers.Histopathologicalexaminationofplacentaerevealedthatinfarctions,
atherosis,hyalinizedareasandTennyParkerschangesweresignificantlyincreasedinpreeclamptic
groupthancontrolgroup.Thepresentstudydidnotfoundanycorrelationsbetweenvisfatinlevels
versushistopathologicalchangesinplacentaeamongpreeclampticmothers.
Conclusions:Hypervisfatinemia maybeoneofthepossibleetiologiesofpreeclampsia.Visfatin
mightbepartofafeedbackmechanism improvinginsulinsensitivity.Preeclampticplacentae
exhibiteddefinitehistopathologicalchangeswhichmaybeattributedtothevascularinsufficiency
ofplacenta