Staff Members - Benha University
Studyofvisfatinlevelanditsrelationtosomehistopathologicalchanges ofplacentaeinpreeclampsi
• 2016
Publication Information
Authors
:M.A.Megahed,S.M.Dawoud,A.I.El-Sarha,M.A.Fayed,andM.I.Ahme
Keywords
Visfatin,Preeclampsia,Insulinresistance,Placenta,Infarction,Atherosis,Hyalinized
areas,TennyParkerchanges
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Objective:Tomeasuretheserum levelofvisfatininpreeclampticEgyptianpregnantwomenand
thepossiblerelationofvisfatinleveltoeachofthemeasuredinsulinresistance,bodymassindex
andhistopathologicalchangesoftheplacentaincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Thepresentstudyresultsrevealedthatpreeclampticmothershadasignificantincreasein
insulinresistancevaluethannormalpregnantwomenwithnosignificantdifferenceinthisvalue
betweenmildandseverepreeclampticsub-groups.Regardingvisfatinlevel,therewasahighly
significantincreaseinvisfatinlevelinpreeclampticwomencomparedwithhealthycontrolsand
alsoincreaseinseverethanmildpreeclampticsub-groups.Correlationanalysispresenteda
significantnegative correlation between maternalvisfatin levelsversusHOMA-IR among
preeclampticgroup,butnorelationhadbeenfoundbetweenvisfatinlevelsandbodymassindex
amongpreeclampticmothers.Histopathologicalexaminationofplacentaerevealedthatinfarctions,
atherosis,hyalinizedareasandTennyParkerschangesweresignificantlyincreasedinpreeclamptic
groupthancontrolgroup.Thepresentstudydidnotfoundanycorrelationsbetweenvisfatinlevels
versushistopathologicalchangesinplacentaeamongpreeclampticmothers.
Conclusions:Hypervisfatinemia maybeoneofthepossibleetiologiesofpreeclampsia.Visfatin
mightbepartofafeedbackmechanism improvinginsulinsensitivity.Preeclampticplacentae
exhibiteddefinitehistopathologicalchangeswhichmaybeattributedtothevascularinsufficiency
ofplacenta
thepossiblerelationofvisfatinleveltoeachofthemeasuredinsulinresistance,bodymassindex
andhistopathologicalchangesoftheplacentaincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Thepresentstudyresultsrevealedthatpreeclampticmothershadasignificantincreasein
insulinresistancevaluethannormalpregnantwomenwithnosignificantdifferenceinthisvalue
betweenmildandseverepreeclampticsub-groups.Regardingvisfatinlevel,therewasahighly
significantincreaseinvisfatinlevelinpreeclampticwomencomparedwithhealthycontrolsand
alsoincreaseinseverethanmildpreeclampticsub-groups.Correlationanalysispresenteda
significantnegative correlation between maternalvisfatin levelsversusHOMA-IR among
preeclampticgroup,butnorelationhadbeenfoundbetweenvisfatinlevelsandbodymassindex
amongpreeclampticmothers.Histopathologicalexaminationofplacentaerevealedthatinfarctions,
atherosis,hyalinizedareasandTennyParkerschangesweresignificantlyincreasedinpreeclamptic
groupthancontrolgroup.Thepresentstudydidnotfoundanycorrelationsbetweenvisfatinlevels
versushistopathologicalchangesinplacentaeamongpreeclampticmothers.
Conclusions:Hypervisfatinemia maybeoneofthepossibleetiologiesofpreeclampsia.Visfatin
mightbepartofafeedbackmechanism improvinginsulinsensitivity.Preeclampticplacentae
exhibiteddefinitehistopathologicalchangeswhichmaybeattributedtothevascularinsufficiency
ofplacenta