Staff Members - Benha University
Maternalserumlevelofadiponectinandmacroscopicchangesofplacentae inpreeclampsi
• 2016
Publication Information
Authors
M.A.Megahed,S.M.Dawoud,A.I.El-Sarha,M.A.Fayed,andM.I.Ahme
Keywords
Adiponectin,Preeclampsia,Insulinresistance,Placent
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
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Abstract
Objective:Tomeasuretheserum levelofadiponectininpreeclampticEgyptianpregnantwomen
andthepossiblecorrelationsofmaternaladiponectinleveltomeasuredinsulinresistanceinsuch
caseandtomacroscopicfeaturesofplacentaeincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Resultsrevealedthatpreeclampticwomenweremoreinsulinresistantwithasignificant
decreaseinadiponectinlevelcomparedwithhealthycontrols.Correlationanalysispresenteda
significantnegativecorrelationbetweenadiponectinlevelsandmeasuredinsulinresistanceamong
preeclampticwomen.Pregnantwomenwithpreeclampsiahadlowerplacentalweightanddecreased
numberofcotyledonswithmarginalinsertionofumbilicalcord.Thepresentstudydidnotfound
anycorrelationsbetweenadiponectinlevelsversusmacroscopicfeaturesofplacentaeamong
preeclampticmothers.
Conclusions:Preeclampticmothersaremoreinsulin resistant,which wasreflected through
increasedHOMA-IRvalue;thisrelationshippostulatesthatinsulinresistancemaybeoneofthe
casualpathwaysofpreeclampsia.Hypoadiponectinemiamaybeoneofthepossibleetiologiesof
preeclampsia.Preeclampticplacentaeexhibiteddefinitemorphologicalchangeswhichmaybe
attributedtothevascularinsufficiencyofplacenta
andthepossiblecorrelationsofmaternaladiponectinleveltomeasuredinsulinresistanceinsuch
caseandtomacroscopicfeaturesofplacentaeincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Resultsrevealedthatpreeclampticwomenweremoreinsulinresistantwithasignificant
decreaseinadiponectinlevelcomparedwithhealthycontrols.Correlationanalysispresenteda
significantnegativecorrelationbetweenadiponectinlevelsandmeasuredinsulinresistanceamong
preeclampticwomen.Pregnantwomenwithpreeclampsiahadlowerplacentalweightanddecreased
numberofcotyledonswithmarginalinsertionofumbilicalcord.Thepresentstudydidnotfound
anycorrelationsbetweenadiponectinlevelsversusmacroscopicfeaturesofplacentaeamong
preeclampticmothers.
Conclusions:Preeclampticmothersaremoreinsulin resistant,which wasreflected through
increasedHOMA-IRvalue;thisrelationshippostulatesthatinsulinresistancemaybeoneofthe
casualpathwaysofpreeclampsia.Hypoadiponectinemiamaybeoneofthepossibleetiologiesof
preeclampsia.Preeclampticplacentaeexhibiteddefinitemorphologicalchangeswhichmaybe
attributedtothevascularinsufficiencyofplacenta