| publication name | Maternalserumlevelofadiponectinandmacroscopicchangesofplacentae inpreeclampsi |
|---|---|
| Authors | M.A.Megahed,S.M.Dawoud,A.I.El-Sarha,M.A.Fayed,andM.I.Ahme |
| year | 2016 |
| keywords | Adiponectin,Preeclampsia,Insulinresistance,Placent |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | International |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Objective:Tomeasuretheserum levelofadiponectininpreeclampticEgyptianpregnantwomen andthepossiblecorrelationsofmaternaladiponectinleveltomeasuredinsulinresistanceinsuch caseandtomacroscopicfeaturesofplacentaeincludedinthisstudy. Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy pregnantwomenduringthethirdtrimester. Results:Resultsrevealedthatpreeclampticwomenweremoreinsulinresistantwithasignificant decreaseinadiponectinlevelcomparedwithhealthycontrols.Correlationanalysispresenteda significantnegativecorrelationbetweenadiponectinlevelsandmeasuredinsulinresistanceamong preeclampticwomen.Pregnantwomenwithpreeclampsiahadlowerplacentalweightanddecreased numberofcotyledonswithmarginalinsertionofumbilicalcord.Thepresentstudydidnotfound anycorrelationsbetweenadiponectinlevelsversusmacroscopicfeaturesofplacentaeamong preeclampticmothers. Conclusions:Preeclampticmothersaremoreinsulin resistant,which wasreflected through increasedHOMA-IRvalue;thisrelationshippostulatesthatinsulinresistancemaybeoneofthe casualpathwaysofpreeclampsia.Hypoadiponectinemiamaybeoneofthepossibleetiologiesof preeclampsia.Preeclampticplacentaeexhibiteddefinitemorphologicalchangeswhichmaybe attributedtothevascularinsufficiencyofplacenta