أعضاء هيئة التدريس - جامعة بنها
Maternalserumlevelofadiponectinandmacroscopicchangesofplacentae inpreeclampsi
• 2016
معلومات البحث
المؤلفون
M.A.Megahed,S.M.Dawoud,A.I.El-Sarha,M.A.Fayed,andM.I.Ahme
الكلمات المفتاحية
Adiponectin,Preeclampsia,Insulinresistance,Placent
المجلة العلمية
Not Available
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
International
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Objective:Tomeasuretheserum levelofadiponectininpreeclampticEgyptianpregnantwomen
andthepossiblecorrelationsofmaternaladiponectinleveltomeasuredinsulinresistanceinsuch
caseandtomacroscopicfeaturesofplacentaeincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Resultsrevealedthatpreeclampticwomenweremoreinsulinresistantwithasignificant
decreaseinadiponectinlevelcomparedwithhealthycontrols.Correlationanalysispresenteda
significantnegativecorrelationbetweenadiponectinlevelsandmeasuredinsulinresistanceamong
preeclampticwomen.Pregnantwomenwithpreeclampsiahadlowerplacentalweightanddecreased
numberofcotyledonswithmarginalinsertionofumbilicalcord.Thepresentstudydidnotfound
anycorrelationsbetweenadiponectinlevelsversusmacroscopicfeaturesofplacentaeamong
preeclampticmothers.
Conclusions:Preeclampticmothersaremoreinsulin resistant,which wasreflected through
increasedHOMA-IRvalue;thisrelationshippostulatesthatinsulinresistancemaybeoneofthe
casualpathwaysofpreeclampsia.Hypoadiponectinemiamaybeoneofthepossibleetiologiesof
preeclampsia.Preeclampticplacentaeexhibiteddefinitemorphologicalchangeswhichmaybe
attributedtothevascularinsufficiencyofplacenta
andthepossiblecorrelationsofmaternaladiponectinleveltomeasuredinsulinresistanceinsuch
caseandtomacroscopicfeaturesofplacentaeincludedinthisstudy.
Studydesign:Thestudypopulationconsistedof30preeclampticpatientsand30matchedhealthy
pregnantwomenduringthethirdtrimester.
Results:Resultsrevealedthatpreeclampticwomenweremoreinsulinresistantwithasignificant
decreaseinadiponectinlevelcomparedwithhealthycontrols.Correlationanalysispresenteda
significantnegativecorrelationbetweenadiponectinlevelsandmeasuredinsulinresistanceamong
preeclampticwomen.Pregnantwomenwithpreeclampsiahadlowerplacentalweightanddecreased
numberofcotyledonswithmarginalinsertionofumbilicalcord.Thepresentstudydidnotfound
anycorrelationsbetweenadiponectinlevelsversusmacroscopicfeaturesofplacentaeamong
preeclampticmothers.
Conclusions:Preeclampticmothersaremoreinsulin resistant,which wasreflected through
increasedHOMA-IRvalue;thisrelationshippostulatesthatinsulinresistancemaybeoneofthe
casualpathwaysofpreeclampsia.Hypoadiponectinemiamaybeoneofthepossibleetiologiesof
preeclampsia.Preeclampticplacentaeexhibiteddefinitemorphologicalchangeswhichmaybe
attributedtothevascularinsufficiencyofplacenta