The present study investigated the effect of inderal
( a nonselective B-blocker ) & atenolol ( A cardioselective
B-blocker ) on fasting serum glucose level & serum glucose
response to subcutaneous insulin in rats.
Both types of B-blockers did not affect the fasting
serum glucose level. Inderal did not affect the drop in blood
glucose 30 minutes after insulin injection. However, in inderal
pretreated rats, the insulin-induced hypoglycaemia was progres
sive during the first hour & only one rat survived till the end
of the second hour. These effects are probably due to attenuated
glycogenolysis & glucoreogenesis_Pretreatment of the rats with