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A study on the effect of B.blockers on blood glucose level in experimenta-1 animals

• 1950
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publication.type Local
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Abstract
The present study investigated the effect of inderal
( a nonselective B-blocker ) & atenolol ( A cardioselective
B-blocker ) on fasting serum glucose level & serum glucose
response to subcutaneous insulin in rats.
Both types of B-blockers did not affect the fasting
serum glucose level. Inderal did not affect the drop in blood
glucose 30 minutes after insulin injection. However, in inderal
pretreated rats, the insulin-induced hypoglycaemia was progres
sive during the first hour & only one rat survived till the end
of the second hour. These effects are probably due to attenuated
glycogenolysis & glucoreogenesis_Pretreatment of the rats with