| publication name | THE EFFECT OF LIDOCAINE; CALCIUM CHANNEL BLOCKING AGENTS AND BETA AGENTS ON URIN FLOW RATE, SODIUM AND POTASSIUM EXCRETION |
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| Authors | |
| year | 1950 |
| keywords | |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Lidocaine has marked antidiuretic effect for 2 1/2 hours (P<0.05), natriuretic effect (P<O.01) and increased K excretion (P<0.01). Verapamil has no significant effect on urine flow rate (P>0.5), but has natriuretic effect (P<0.05) and no significant changes on K excretion (P>0.05). Propranolol has no significant effect on urine flow (P>0.05), decrease Na excretion (P<0.05), but has no effect on K excretion (P>0.05). The combined effect of Lidocaine and Verapamil showed that the antidiuretic action of Lidocaine is regressed for 1/2 hour. It has a natriuretic effect (P<0.01) and causes marked increased K excretion (P<0.01). Combination of Lidocaine_ with Propranol showed marked inhibitory effect on urine flow (P<0.01), significant decrease in Na excretion (P<0.05) and significant increase in K excretion (P<0.05).