An growth experiment was conducted to investigate the effect of partial or complete replacement of Fish Meal (FM) by dried Fermented Fish By-product Silage (FFS) in diets of African catfish(Clarias gariepinus). Five dry pelleted diets containing 0, 25, 50, 75 and 100% FFS to replace the same percent of FM (on protein content basis) were prepared to be isonitrogenous (30% CP) and isocaloric (2700 kcal ME/kg diet) and tested in 3 months feeding experiment. Catfish (4.11-4.21 g) were fed the tested diets twice daily for six days a week in triplicate groups experiment. Results indicated that, dried FFS can successfully replace up to 50% of FM in catfish diets without any significant (P