ABSTRACT The present study was to evaluate hepatoprotective effects of cranberry extract (75 and 150mg/kg.b.w) against Diclofenac sodium induced liver toxicity in rats. Oral administration of Diclofenac sodium (150mg/kg.b.w.) led to significant increase in plasma transaminases (L-alanine and L-aspartate), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), tumor necrosis factor-alfa (TNF-α), nitric oxide (NO) and TBARS as well as plasma, triglyceride, total cholesterol, and LDL-cholesterol. Also, treatment of rats with Diclofenac sodium led to significant decrease in liver GSH, Protein thiols (Pr-SHs), superoxide dismutase (SOD), catalase (CAT) as well as plasma HDL. The obtained result revealed that cranberry extract (75 and 150mg/kg.b.w.) prevent liver tissue damage through increasing of GSH, SOD and CAT activities and decrease significantly TBARs level. These results suggest that, cranberry may be effective in enhances the protection of liver toxicity by its radical scavenging effect and antioxidant activity.