Staff Members - Benha University
Hepatoprotective Effects of Cranberry Extract against Diclofenac Sodium Induced Liver Toxicity in Rats
Intternattiionall Journall of Pharma Sciiences • 2016
Publication Information
Authors
Abdel-Maksoud A. Hussien1, Mohammed Abdalla Hussein*2, Naglaa Abd El Khalik Gobba3 and Mahmoud Rabie Ahmed1
Keywords
Diclofenac sodium, liver toxicity, cranberry, Antioxidant enzymes, lipid profile, GSH.
Journal
Intternattiionall Journall of Pharma Sciiences
Publisher
aizeon publisher
Volume
Vol. 6
Issue
No. 2 (2016)
Pages
1447-1453
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
ABSTRACT
The present study was to evaluate hepatoprotective effects of cranberry extract (75 and 150mg/kg.b.w) against Diclofenac sodium induced liver toxicity in rats. Oral administration of Diclofenac sodium (150mg/kg.b.w.) led to significant increase in plasma transaminases (L-alanine and L-aspartate), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), tumor necrosis factor-alfa (TNF-α), nitric oxide (NO) and TBARS as well as plasma, triglyceride, total cholesterol, and LDL-cholesterol. Also, treatment of rats with Diclofenac sodium led to significant decrease in liver GSH, Protein thiols (Pr-SHs), superoxide dismutase (SOD), catalase (CAT) as well as plasma HDL. The obtained result revealed that cranberry extract (75 and 150mg/kg.b.w.) prevent liver tissue damage through increasing of GSH, SOD and CAT activities and decrease significantly TBARs level. These results suggest that, cranberry may be effective in enhances the protection of liver toxicity by its radical scavenging effect and antioxidant activity.
The present study was to evaluate hepatoprotective effects of cranberry extract (75 and 150mg/kg.b.w) against Diclofenac sodium induced liver toxicity in rats. Oral administration of Diclofenac sodium (150mg/kg.b.w.) led to significant increase in plasma transaminases (L-alanine and L-aspartate), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), tumor necrosis factor-alfa (TNF-α), nitric oxide (NO) and TBARS as well as plasma, triglyceride, total cholesterol, and LDL-cholesterol. Also, treatment of rats with Diclofenac sodium led to significant decrease in liver GSH, Protein thiols (Pr-SHs), superoxide dismutase (SOD), catalase (CAT) as well as plasma HDL. The obtained result revealed that cranberry extract (75 and 150mg/kg.b.w.) prevent liver tissue damage through increasing of GSH, SOD and CAT activities and decrease significantly TBARs level. These results suggest that, cranberry may be effective in enhances the protection of liver toxicity by its radical scavenging effect and antioxidant activity.