| publication name | EVALUATION OF (PARP-1) EXPRESSION IN GASTRIC CARCINOMA BY IMMUNOHISTOCHEMISTRY AND QUANTITATIVE REAL-TIME PCR AND ITS RELATION TO HER2 STATUS. |
|---|---|
| Authors | Marwa Said Abd Allaha , Heba mohammed Abd El Kariemb ,Heba Mohammed Rashada. |
| year | 2020 |
| keywords | Key Words: PARP-1, HER2, gastric carcinoma, Immunohistochemistry, Quantitative Real-Time PCR. |
| journal | The Medical Journal of Cairo University |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Abstract: Background: PARP-1 overexpression has been identified in several malignancies. Few studies have handled the expression of PARP-1 protein in gastric carcinoma and its associations with outcome. This work aimed at exploring the significance of PARP-1 expression in gastric adenocarcinoma and correlation with HER2 status Methods: Quantitative expression of PARP-1 proteins was assayed by Immunohistochemistry in 40 cases of gastric adenocarcinoma. PARP-1 mRNA was moreover evaluated by Quantitative Real-Time Polymerase Chain Reaction. Results: The level of expression of mRNA expression level was significantly increased in 25 of 40 (62.5%) of gastric adenocarcinoma tissues compared with the corresponding adjacent non cancer tissues (P