أعضاء هيئة التدريس - جامعة بنها
EVALUATION OF (PARP-1) EXPRESSION IN GASTRIC CARCINOMA BY IMMUNOHISTOCHEMISTRY AND QUANTITATIVE REAL-TIME PCR AND ITS RELATION TO HER2 STATUS.
The Medical Journal of Cairo University • 2020
معلومات البحث
المؤلفون
Marwa Said Abd Allaha , Heba mohammed Abd El Kariemb ,Heba Mohammed Rashada.
الكلمات المفتاحية
Key Words: PARP-1, HER2, gastric carcinoma, Immunohistochemistry, Quantitative Real-Time PCR.
المجلة العلمية
The Medical Journal of Cairo University
الناشر
Not Available
المجلد
Not Available
العدد
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الصفحات
Not Available
publication.type
Local
رابط البحث
Not Available
المواد المرفقة
Not Available
الملخص
Abstract:
Background: PARP-1 overexpression has been identified in several malignancies. Few studies have handled the expression of PARP-1 protein in gastric carcinoma and its associations with outcome. This work aimed at exploring the significance of PARP-1 expression in gastric adenocarcinoma and correlation with HER2 status
Methods: Quantitative expression of PARP-1 proteins was assayed by Immunohistochemistry in 40 cases of gastric adenocarcinoma. PARP-1 mRNA was moreover evaluated by Quantitative Real-Time Polymerase Chain Reaction.
Results: The level of expression of mRNA expression level was significantly increased in 25 of 40 (62.5%) of gastric adenocarcinoma tissues compared with the corresponding adjacent non cancer tissues (P
Background: PARP-1 overexpression has been identified in several malignancies. Few studies have handled the expression of PARP-1 protein in gastric carcinoma and its associations with outcome. This work aimed at exploring the significance of PARP-1 expression in gastric adenocarcinoma and correlation with HER2 status
Methods: Quantitative expression of PARP-1 proteins was assayed by Immunohistochemistry in 40 cases of gastric adenocarcinoma. PARP-1 mRNA was moreover evaluated by Quantitative Real-Time Polymerase Chain Reaction.
Results: The level of expression of mRNA expression level was significantly increased in 25 of 40 (62.5%) of gastric adenocarcinoma tissues compared with the corresponding adjacent non cancer tissues (P