Background The incidence of endometrial carcinoma among Egyptian women has increased in the past few years. This work was performed to evaluate the role of autophagy marker Beclin-1 in endometrial carcinoma type I and correlate it with progesterone receptor (PR) and Bcl-2 expression. Materials and methods This retrospective study included 30 cases of endometrial carcinoma type I, eight cases of endometrial hyperplasia with atypia, and seven cases of endometrial hyperplasia without atypia. Cases were collected from archives of Pathology Department and Early Cancer Detection Unit, Faculty of Medicine, Benha University, through the years 2011 to 2017. Beclin-1, Bcl-2, and PR immunohistochemichal staining was performed on all cases, and the patterns of expression were analyzed. Results Beclin-1 was expressed in 36.7, 62.5, and 71.5% of endometrial carcinoma, endometrial hyperplasia with atypia, and hyperplasia without atypia, respectively. This showed a statistically significant difference (P