Staff Members - Benha University
Relation of autophagy to apoptosis and progesterone receptor expression in endometrial carcinoma type I.
Egyptian Journal of Pathology • 2019
Publication Information
Authors
Heba M Rashad, Ghada A.Abd El-Fattah, Gehan M Elosaily
Keywords
apoptosis, autophagy, Bcl-2, Beclin-1, endometrial carcinoma, PR
Journal
Egyptian Journal of Pathology
Publisher
Not Available
Volume
39
Issue
1
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background
The incidence of endometrial carcinoma among Egyptian women has increased in
the past few years. This work was performed to evaluate the role of autophagy
marker Beclin-1 in endometrial carcinoma type I and correlate it with progesterone
receptor (PR) and Bcl-2 expression.
Materials and methods
This retrospective study included 30 cases of endometrial carcinoma type I, eight
cases of endometrial hyperplasia with atypia, and seven cases of endometrial
hyperplasia without atypia. Cases were collected from archives of Pathology
Department and Early Cancer Detection Unit, Faculty of Medicine, Benha
University, through the years 2011 to 2017. Beclin-1, Bcl-2, and PR
immunohistochemichal staining was performed on all cases, and the patterns of
expression were analyzed.
Results
Beclin-1 was expressed in 36.7, 62.5, and 71.5% of endometrial carcinoma,
endometrial hyperplasia with atypia, and hyperplasia without atypia, respectively.
This showed a statistically significant difference (P
The incidence of endometrial carcinoma among Egyptian women has increased in
the past few years. This work was performed to evaluate the role of autophagy
marker Beclin-1 in endometrial carcinoma type I and correlate it with progesterone
receptor (PR) and Bcl-2 expression.
Materials and methods
This retrospective study included 30 cases of endometrial carcinoma type I, eight
cases of endometrial hyperplasia with atypia, and seven cases of endometrial
hyperplasia without atypia. Cases were collected from archives of Pathology
Department and Early Cancer Detection Unit, Faculty of Medicine, Benha
University, through the years 2011 to 2017. Beclin-1, Bcl-2, and PR
immunohistochemichal staining was performed on all cases, and the patterns of
expression were analyzed.
Results
Beclin-1 was expressed in 36.7, 62.5, and 71.5% of endometrial carcinoma,
endometrial hyperplasia with atypia, and hyperplasia without atypia, respectively.
This showed a statistically significant difference (P