Staff Members - Benha University
Nuclear factor - Erythroid 2 - related factor2 Gene Polymorphisms in vitiligo patients
• 2021
Publication Information
Authors
SOROUR NE1
, ABD EL-KAREEM HM2
, IBRAHIM AE3
, SALEM RM4
Keywords
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Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
Background: Oxidative stress is now one of the accepted theories of vitiligo
development. Nuclear factor - Erythroid 2 - related factor 2 (Nrf2) regulates the
expression of anti-oxidant proteins.
Aim of the work: This work aimed to evaluate the association of Nrf2 gene
polymorphisms with the susceptibility to vitiligo among a sample of Egyptian vitiligo
patients.
Participants and methods: This case-control study was performed on 100 patients
suffering from vitiligo and 50 apparently healthy matched volunteers as a control
group. Genotyping was carried out by Real Time PCR.
Results
The frequency of TT, CT, combined (TT+CT) genotypes and T allele of Nrf2
(rs35652124) were significantly increased in the studied vitiligo patients when
compared with healthy controls (P
development. Nuclear factor - Erythroid 2 - related factor 2 (Nrf2) regulates the
expression of anti-oxidant proteins.
Aim of the work: This work aimed to evaluate the association of Nrf2 gene
polymorphisms with the susceptibility to vitiligo among a sample of Egyptian vitiligo
patients.
Participants and methods: This case-control study was performed on 100 patients
suffering from vitiligo and 50 apparently healthy matched volunteers as a control
group. Genotyping was carried out by Real Time PCR.
Results
The frequency of TT, CT, combined (TT+CT) genotypes and T allele of Nrf2
(rs35652124) were significantly increased in the studied vitiligo patients when
compared with healthy controls (P