Background: Oxidative stress is now one of the accepted theories of vitiligo
development. Nuclear factor - Erythroid 2 - related factor 2 (Nrf2) regulates the
expression of anti-oxidant proteins.
Aim of the work: This work aimed to evaluate the association of Nrf2 gene
polymorphisms with the susceptibility to vitiligo among a sample of Egyptian vitiligo
patients.
Participants and methods: This case-control study was performed on 100 patients
suffering from vitiligo and 50 apparently healthy matched volunteers as a control
group. Genotyping was carried out by Real Time PCR.
Results
The frequency of TT, CT, combined (TT+CT) genotypes and T allele of Nrf2
(rs35652124) were significantly increased in the studied vitiligo patients when
compared with healthy controls (P