Staff Members - Benha University
The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma
• 2020
Publication Information
Authors
Eman Mohamed Said Zedan Hanaa Mohamed Ali Abostate. Hala Adel Agina, Nashwa Mohamed Emara
Keywords
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publication.type
Local
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Supplementary Materials
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Abstract
Background: Colorectal carcinoma (CRC) is the third most common
cancer in the world constituting about 10% of all cancers. ALDH1A1 has
been used as a stem cell marker, and plays important functional roles in
stem cells. Expression of ALDH1A1 by cancer stem cells (CSCs) has
been demonstrated in multiple types of cancers.
Aim: This work aimed to evaluate ALDH1A1 expression in colorectal
adenocarcinoma and determine the relation between ALDH1A1
expression and different clinico-pathological variables.
Material and method: This is a selected retrospective study included 50
different cases of colorectal adenocarcinoma. ALDH1A1 immunostaining
was performed for all cases.
Results: There was a highly significant statistical difference between
ALDH1A1 expression in studied cases according to tumor site, lymph
node metastasis and TNM stage (P value
cancer in the world constituting about 10% of all cancers. ALDH1A1 has
been used as a stem cell marker, and plays important functional roles in
stem cells. Expression of ALDH1A1 by cancer stem cells (CSCs) has
been demonstrated in multiple types of cancers.
Aim: This work aimed to evaluate ALDH1A1 expression in colorectal
adenocarcinoma and determine the relation between ALDH1A1
expression and different clinico-pathological variables.
Material and method: This is a selected retrospective study included 50
different cases of colorectal adenocarcinoma. ALDH1A1 immunostaining
was performed for all cases.
Results: There was a highly significant statistical difference between
ALDH1A1 expression in studied cases according to tumor site, lymph
node metastasis and TNM stage (P value