Background: Colorectal carcinoma (CRC) is the third most common
cancer in the world constituting about 10% of all cancers. ALDH1A1 has
been used as a stem cell marker, and plays important functional roles in
stem cells. Expression of ALDH1A1 by cancer stem cells (CSCs) has
been demonstrated in multiple types of cancers.
Aim: This work aimed to evaluate ALDH1A1 expression in colorectal
adenocarcinoma and determine the relation between ALDH1A1
expression and different clinico-pathological variables.
Material and method: This is a selected retrospective study included 50
different cases of colorectal adenocarcinoma. ALDH1A1 immunostaining
was performed for all cases.
Results: There was a highly significant statistical difference between
ALDH1A1 expression in studied cases according to tumor site, lymph
node metastasis and TNM stage (P value