This experiment was conducted under greenhouse conditions using a randomized complete block design (RCBD) with three replicates in the experimental farm station of Fac. Agric. at Moshtohor during 2011 season.This research aims to study the effect of tomato and pepper inoculation with salt-tolerant PGPR isolates (Pseudomonas fluorescence D23, Bacillus pumilus D135 and Azospirillum lipoferum D178) for tomato while, (Bacillus megaterium D159, Paenibacillus alvie D139 and Azospirillum lipoferum D207) for pepper in combination with humic acid and organic manure (compost) on some microbial enzymes activity such as dehydrogenase, phosphatase, nitrogenase and oxidative enzymes like nitrate reductase, peroxidase and polyphenol oxidase. The application of salt-tolerant PGPR in combination with compost at a rate of 10 ton/fed. and humic acid at a rate of 4 kg/fed. gave positive impact on the tested enzymes which resulted to beneficial effect on tomato and pepper cultivated under saline stress. Key words: PGPR, saline stress, oxidative enzymes, microbial enzymes, pepper and tomato.