Staff Members - Benha University
The Anti-Diabetic and Anti-Lipidemic Effects of Peganum harmala Seeds in Diabetic Rats.
. Der Pharmacia Lettre • 2016
Publication Information
Authors
8. Abd El Baky, H.H., Abd EL Rahman, A.A. Mekawi, E. M., Ibrahem, E.A. and Shalapy, N.M.
Keywords
Diabetes Mellitus, Peganum harmala, Hyperglycemia, Diabetic rats, Streptozotocin.
Journal
. Der Pharmacia Lettre
Publisher
Not Available
Volume
8
Issue
10
Pages
1-10
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
This study was performed to determine the influence of the Peganum harmala L. (Zygophyllaceae) on rats as the
antidiabetic factor. Some biochemical parameters and histological were realizated in this study. Also antioxidant
activities were performed. Hypoglycemic activity of the seeds oil extract was realizated at 100 mg/kg b.w. dose
level in the treated rats with streptozotocin (STZ). In comparison between Glucophage as hypoglycemic drug and
the seeds oil extract was studied. Oral administration of Peganum harmala seeds oil extract modulated the diabetic
elevation in the level of blood glucose and alpha amylase activity revealing the anti-hyperglycemic. Seeds oil extract
effectively decreased the total cholesterol, total lipids and triglycerides levels with consequence decrease in alpha
amylase activity. Furthermore, it decreased lipid peroxidation product MD and increased the activities of catalase
and superoxide dismutase enzymes. It could be concluded that the current P. harmala has many benefit procedures
in controlling blood glucose and harmful results induced in pancreas and liver and may be select as a natural
antidiabetic drug.
antidiabetic factor. Some biochemical parameters and histological were realizated in this study. Also antioxidant
activities were performed. Hypoglycemic activity of the seeds oil extract was realizated at 100 mg/kg b.w. dose
level in the treated rats with streptozotocin (STZ). In comparison between Glucophage as hypoglycemic drug and
the seeds oil extract was studied. Oral administration of Peganum harmala seeds oil extract modulated the diabetic
elevation in the level of blood glucose and alpha amylase activity revealing the anti-hyperglycemic. Seeds oil extract
effectively decreased the total cholesterol, total lipids and triglycerides levels with consequence decrease in alpha
amylase activity. Furthermore, it decreased lipid peroxidation product MD and increased the activities of catalase
and superoxide dismutase enzymes. It could be concluded that the current P. harmala has many benefit procedures
in controlling blood glucose and harmful results induced in pancreas and liver and may be select as a natural
antidiabetic drug.