Summary. In this group we would like to answer the question
why people show a diff erent response against certain pathogens.
In many infections the course of the disease can range
from asymptomatic carriage to the severest forms even death.
In the past we have analysed candidate genes and their role in
the course of malaria and could detect some polymorphisms
infl uencing infectious diseases in the genes encoding NOS2,
MBL2, IFNa, FCN2, and receptors for IFNg and IFNa. Having
worked initially mainly on malaria we broadened our spectrum
also to other infectious diseases like hepatitis B, Leprosy,
schistosomiasis. Here we give a short overview about ongoing
projects.
Key words: Malaria, leprosy, HBV, interferon, NK cells, host
genetics.
Association of regulatory gene polymorphisms