The viability and efficiency of ginger oil against liver cirrhosis caused by Thioacetamide (TAA) in rats were investigated. Ginger oil having phenolic content of 85.3 mg g-1 as gallic acid, was extracted from dried ginger rhizome. Chemical composition of the oil was identified by GC-Ms .The major compounds were 1,8-Cineole 16.58% , Zingiberene 10.94%, α- Curcumen 7.66%, β-Sesqu-iphellandrene 6.26%, Camphene 5.93%, Farnesene 4.54%, Linalool 2.76% and β-Myrcene 2.18%. A biological experiment was done at the end. Evaluation of liver and kidney functions were measured. Protein and lipid profiles as well as antioxidant markers were also studied. The obtained results revealed that administration with ginger oil caused positive protective effect against the TAA-induced oxidative damage in liver.