In the current business environment, flexibility and responsiveness to customer requirements and market changes determines to a far extent the company's capability to survival. Companies should focus on selecting/adopting the most suitable improvement initiatives that support their strategic objectives, in order to remain competitive. They usually select performance improvement initiatives to enhance their internal processes and handle such working challenges. Many tools/approaches are available that can be implemented for process improvements. The appropriate selection for the most suitable tool/approach can be appreciated especially before utilizing or investing resources. The current paper introduces a proposed framework to support manufacturing organizations in selecting and determining suitable performance improvements initiative(s). The proposed model is adopted by a home appliance manufacturing firm located in Egypt starting from 2013 to set the firm strategic objectives, and to support operations managers to select the suitable improvement initiatives, significant results related to improving quality rate, increasing throughput, reducing customer returns and manufacturing costs were reported during executives review meeting.