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EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool
• 2013
Publication Information
Authors
Evan Colletti,* Deena El Shabrawy,*,1 Melisa Soland,*‖ Takashi Yamagami,*,2 Saloomeh Mokhtari,*‖ Craig Osborne,† Karen Schlauch,‡§ Esmail D. Zanjani,* Christopher D. Porada,*‖ and Graça Almeida-Porada*‖,
Keywords
crypts of Lieberkühn, transcriptome, Musashi-1, epithelial, Lgr5, transplant, niche
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
To identify human bone marrow stromal cell (BMSC) subsets with enhanced ability to engraft/contribute to the resident intestinal cellular pool, we transplanted clonally derived BMSCs into fetal sheep. Analysis at 75 d post-transplantation showed 2 of the 6 clones engrafting the intestine at 4- to 5-fold higher levels (5.03±0.089 and 5.04±0.15%, respectively) than the other clones (P