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EphB2 isolates a human marrow stromal cell subpopulation with enhanced ability to contribute to the resident intestinal cellular pool

• 2013
العودة
معلومات البحث
المؤلفون Evan Colletti,* Deena El Shabrawy,*,1 Melisa Soland,*‖ Takashi Yamagami,*,2 Saloomeh Mokhtari,*‖ Craig Osborne,† Karen Schlauch,‡§ Esmail D. Zanjani,* Christopher D. Porada,*‖ and Graça Almeida-Porada*‖,
الكلمات المفتاحية crypts of Lieberkühn, transcriptome, Musashi-1, epithelial, Lgr5, transplant, niche
المجلة العلمية Not Available
الناشر Not Available
المجلد Not Available
العدد Not Available
الصفحات Not Available
publication.type International
رابط البحث Not Available
المواد المرفقة Not Available
الملخص
To identify human bone marrow stromal cell (BMSC) subsets with enhanced ability to engraft/contribute to the resident intestinal cellular pool, we transplanted clonally derived BMSCs into fetal sheep. Analysis at 75 d post-transplantation showed 2 of the 6 clones engrafting the intestine at 4- to 5-fold higher levels (5.03±0.089 and 5.04±0.15%, respectively) than the other clones (P